Neoplasms in rats treated with pituitary growth hormone. III. Reproductive organs.

This paper deals with the neoplastic and hyperplastic changes in the ovaries, uteri, and mammary glands of rats treated with growth hormone. Ab normalities of these organs occurred in 12 of 15 female rats following the administration of pitui tary growth hormone for long periods. The neo plasms occurring in the lungs, lymphatic tissues, and adrenal glands of these rats have been redosage of growth hormone was 0.4 nig. ; this was increased at intervals to a maximum of 3.0 mg. A similar group of adult females was injected parenterally with comparable amounts of albumin. Serial sections of the ovaries were prepared. The uterine horns were fixed, and blocks of tissue from both horns were taken for microscopic examina tion. The mammary glands were examined both